Given number series is 5 19 49 101 181 295 ?
Here the series follows pattern that
5 19 49 101 181 295 ?
14 30 52 80 114 (difference)
16 22 28 34 (difference)
6 6 6 (Common difference)
Therefore, the missing number in the series is ? = 295 + 115 + 34 + 6 = 449.