Total number of ways of filling the 5 boxes numbered as (1, 2, 3, 4, and 5) with either blue or red balls 25 = 32.
Two adjacent boxes with blue can be obtained in 4 ways, i.e., (12), (23), (34) and (45).
Three adjacent boxes with blue can be obtained in 3 ways, i.e., (123), (234)and (345). Four boxes with blue can be obtained in 2 ways, i.e., (1234) and (2345). And five boxes with blue can be got in 1 way. Hence, the number of ways of filling the boxes such that adjacent boxes have blue
= (4 + 3 + 2 + 1) = 10.
Hence, the number or ways of filling up the boxes such that no two adjacent boxes have blue = 32 - 10 = 22.