Correct Answer: 81
Explanation:
The series follows the following pattern.
4
16 = 4 2
37 = 1 2 + 6 2
58 = 3 2 + 7 2
81 ≠ 5 2 + 8 2 .
Here every number is based on the digits of previous number. Hence, 81 is the wrong number in the given series.